Two-Eighty was used by Sgt. Marcus Fenix, Pvt. Dominic Santiago, Pvt. Tai Kaliso, and Pvt. Padrick Salton, who was driving, after the recall to Ephyra was issued. However, when they heard that Jannermont was under attack, they left their route and headed to assist the city. After killing a group of Locust in a general store, they loaded the wounded civilians into Two-Eighty and took them to a first-aid station. After they got back on route, Two-Eighty began experiencing engine trouble, which Pad was unable to fix. They stripped Two-Eighty of all useful parts, and abandoned it on the side of the road.